Jin Weilin
Published:2014-03-07 Hits:2272

Associate Professor Jin weilin
Jin Wei-Lin, male, MD, associate professor.  In 1994, he graduated from Wuhan University in biochemistry and received a Bachelor's degree. In 2004, he graduated from the fourth military medical University Institute for Neuroscience Neurobiology and get doctor's degree. In 2005, he switched to Shanghai Jiaotong University, was hired as an associate researcher at the Shanghai Jiaotong University. He interested in molecular signatures of the development and regeneration of the central nervous system and brain tumor molecular interventions. His papers were published in Cell、Cell Death and Differention、Nature communications、Mol Cell Neurosci、Anesthesiology、J Comp Neurol、Cell Mol Neurobiol、Neurosignals、Neurosci Lett. His research outcomes are cited and concerned broadly. Now ,he is the member of the Chinese society for Neuroscience and Nano-Oncology speciality Committee of Chinese anti-cancer Association.
Hosted project:
Currently, he presided four National Science Fund projects: “the mechanism of malignant glial tumor development of oxidation restore addiction signal guided by Nogo-A” “the double regulation mechanism of spirit development hysteresis candidate gene MEGAP/srGAP3 regulation tree bursting development ” “the double regulation mechanism of neurons Nogo editing isomers on protrusions growth and cell apoptosis died  ” “the targeted research of nNOS gene as neurons nucleus Nogo-A protein”
Main research directions of laboratory :
At present, the laboratories forms a stable research direction in neurobiology and molecular biology of tumors :
1. Molecular mechanisms of neural development and developmental disorders;
2.the molecular signals of central nervous system injury and regeneration .
3. Malignant gliomas molecular interventions
4. Epigenetics
The major outcomes in recent years:
1. Lu H, Jiao Q, Wang YY, Yang ZQ, Feng MJ, Wang L, Chen XL, Jin WL*, Liu Y*. The mental retardation associated protein srGAP3 regulates survival, proliferation and differentiation of rat embryonic neural stem/progenitor cells. Stem Cells and Development. June 2013, 22(11): 1709-1716.
2. Guo F#, Jin WL#, Li LY, Song WY, Wang HW, Gou XC, Mi YJ, Wang Q*, Xiong L*. M9, A Novel Region of Amino-Nogo-A, Attenuates Cerebral Ischemic Injury by Inhibiting NADPH Oxidase-Derived Superoxide Production in Mice.CNS Neurosci Ther. 2013 May; 19(5):319-28.
3. Guo F, Wang H, Li L, Zhou H, Wei H, Jin WL, Wang Q*, Xiong L*. A Novel Domain of Amino-Nogo-A Protects HT22 Cells Exposed to Oxygen Glucose Deprivation by Inhibiting NADPH Oxidase Activity. Cell Mol Neurobiol. 2013 April, 33(3): 443-452
4. Ma Y#, Mi YJ#, Dai YK, Fu HL, Cui DX and Jin WL*. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells. Plos One. 2013 Mar 7; e57865.
5. Niu NN#, Liang WQ#, Yang XJ, Jin WL, Wilson ZA, Hu JP, Zhang DB*. EAT1 promotes tapetal cell death by regulating aspartic proteases during male reproductive development in rice. Nat Commun. 2013 Feb 5;4:1445.
6. Gao G*, Zhang CL, Zhou ZJ, Zhang X, Ma JB, Li C, Jin WL* and Cui DX*. One-pot hydrothermal synthesis of lanthanide ions doped one-dimensional upconversion submicrocrystals and their potential application in vivo CT imaging. Nanoscale. 2012 Dec 6;5(1):351-62.
7. Chen J, Wang W, Zhang T, Ji JJ, Qian QR, Lu LG, Fu HL, Jin WL, Cui DX. Differential  expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer. PLoS One. 2012;7(10):e47563.
8. Charrier C, Joshi K, Coutinho-Budd J, Kim J, Lambert N, Jacqueline de Marchena, Jin WL, Vanderhaeghen P, Ghosh A, Sassa K and Polleux F. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny of spine maturation. Cell Volume 149, Issue 4, 11 May 2012, Pages 923-935.
        News&Views in Nature by Geschwind and Konopka. Highlights in Nature by Ewen Callaway. Discover Magazine by Ed Yong. New Scientist by Sara Reardon.
9. MiYJ, Hou B, Liao QM, Ma Y, Luo Q, Dai YK, Gong Ju, Jin WL*. Amino-Nogo-A antagonizes reactive oxygen species generation and protects immature primary cortical neurons from oxidative toxicity. Cell Death Differ. 2012 Jul; 19 (7):1175-86.
10. Chen K, Mi YJ, Ma Y, Fu HL, Jin WL*. The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells. Cell Mol Neurobiol. 2011 Jul; 31(5):675-86.
11. Guerrier S, Coutinho-Budd J, Sassa T, Gresset A, Jordan NV, Chen K, Jin WL, Frost A, Polleux F. The F-BAR Domain of srGAP2 Induces Membrane Protrusions Required for Neuronal Migration and Morphogenesis. Cell. 2009 Sep; 138 (5): 990-1004. (Mini review in Development Cell. Calson BR and Soderling S. 2009)
12. Wang Q, Gou X, Jin WL, Xiong L, Hou L, Chen S, Zhang H, Zhu X, Xu L. TAT-Mediated Protein Transduction of Nogo Extracellular Peptide 1-40 and its Biological Activity. Cell Mol Neurobiol. 2009 Feb; 29 (1):97-108.
13. Wang Q, Gou XC, Xiong LZ, Jin WL, Chen S, Hou L, Xu L.Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosis. Anesthesiology. 2008 Jun; 108 (6):1071-80.
14. Zhao XH, Jin WL*#, Wu J, Mi S and Ju G*. Inactivation of Glycogen Synthase Kinase-3beta and Up-regulation of LINGO-1 are Involved in LINGO-1 Antagonist Regulated Survival of Cerebellar Granular Neurons. Cell Mol Neurobiol. 2008 Aug; 28 (5): 727-735.
15. Yao Q, Jin WL*#, Wang Y, Ju G*. Regulated Shuttling of Slit-Robo-GTPase Activating Proteins Between Nucleus and Cytoplasm During Brain Development. Cell Mol Neurobiol. 2008 Feb; 28(2):205-221.
16. Zhao XH, Jin WL*#, and Ju G*. An in vitro study on the involvement of LINGO-1 and Rho GTPases in Nogo-A regulated differentiation of oligodendrocyte precursor cells. Mol Cell Neurosci. 2007 Oct; 36 (2):260-9.
17. Liu X, Liu YY, Jin WL, Liu HL and Ju G. Nogo-66 receptor at cerebellar cortical glia gap junctions in the rat. Neurosignals. 2005; 14 (3): 96-101.
18. He WX, Niu ZY, Zhao SL, Jin WL, Gao J, Smith AJ. TGF-beta activated Smad signalling leads to a Smad3-mediated down-regulation of DSPP in an odontoblast cell line. Arch Oral Biol. 2004, Nov; 49 (11): 911-918.
19. Liu YY, Jin WL, Liu HL, Ju G. Electron microscopic localization of Nogo-A at the postsynaptic active zone of the rat. Neuroscience Letters. 2003, Aug; 346 (3): 153-156.
20. Jin WL, Liu YY, Liu HL, Yang H, Wang Y, Jiao XY, Ju G. Intraneuronal localization of Nogo-A in the rat. J Comp Neurol. 2003 Mar 24; 458 (1):1-10

Research group of Shanghai ICP 11031250 -1 2013 Shanghai Jiao Tong University pollution control

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