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刘聪教授学术报告
发表时间:2019-04-09 阅读次数:433次

报告题目:The structural basis of reversible fibril involved in phase separation and neurodegenerative diseases

报告时间:2019年04月11日10:00

报告地点:电院群楼2-314

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报告简介:

Pathological amyloid fibrils are characteristic of highly thermostable cross-β structure. However, the stable cross-β architecture cannot explain the reversible amyloid fibrils formed by RNA-binding proteins such as hnRNPA1 and FUS that is involved in the dynamic assembly of stress granules. In this seminar, I will introduce our recent work on identification and structural characterization of highly reversible amyloid fibrils formed by hnRNPA1 and FUS by using our newly developed method – microED. Together with biochemical and cellular experiments, we demonstrated the essential role of reversible fibrils in phase separation and stress granule formation, dysregulation of which may lead to pathology.

报告人简介:

刘聪,现任中国科学院生物与化学交叉研究中心研究员,博士生导师。入选中组部青年千人计划,主持并参与多个基金项目,包括:科技部青年863、科技部蛋白质重大专项计划、自然科学基金委重大计划及面上项目,以及上海科委项目。应邀担任Medical Research Council(MRC)research grant proposal、Nature Chemistry、Molecular Cell、JACS等期刊的特约审稿人。共发表文章近30篇,Google scholar合计总引用率1800余次。近三年以通讯作者身份在Nature Structural & Molecular Biology、Cell、 PNAS、Nature Communication、Cell Research、JACS和Angewandte等发表多篇论文。

研究领域:聚焦与神经退行性疾病如阿尔兹海默病、帕金森病及渐冻人病等相关的蛋白质的错误折叠,液态-液态相分离,和淀粉样聚集的分子机理及结构基础研究。发展新颖的结构解析技术与平台(如蛋白质纳米级晶体电子衍射,in-cell NMR等)来研究致病蛋白聚集的分子机制和结构基础。通过大规模药物筛选以及基于结构的药物设计,发展针对帕金森病及渐冻人病的致病蛋白聚集体的早期诊断试剂分子以及抑制聚集及细胞毒性的小分子及抗体药物。基于淀粉样多肽原子结构的具有全新功能的新型生物纳米材料的设计,开发和应用。

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