Prof. Chen received his B.S. in 1993 and M.S. in 1996 from Nanjing University, China. He then moved to the states and obtained his Ph.D. in chemistry from the University of Idaho in 1999 under the supervision of Professor Chien M. Wai. After two quick postdoctoral programs at Syracuse University (under the mentorship of Dr. Jon Zubieta) and Washington University in St. Louis (supervised by Professor Michael J. Welch), Dr. Chen joined the University of Southern California as an Assistant Professor of Radiology. He then moved to Stanford University in 2004 to help build the Molecular Imaging Program at Stanford (MIPS) under the directorship of Professor Sanjiv Sam Gambhir, and was promoted to Associate Professor in 2008. In the summer of 2009, he joined the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) as a tenured Senior Investigator. Dr. Chen also holds a joint appointment with the NIH Clinical Center.
LOMIN specializes in synthesizing molecular imaging probes for positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), optical (bioluminescence, fluorescence and Raman), contrast enhanced ultrasound, photoacoustic imaging, as well as multimodality imaging. This research group aims to develop molecular imaging toolbox for better understanding of biology, early diagnosis of disease, monitoring therapy response, and guiding drug discovery/development. LOMIN puts special emphasis on high-sensitivity nanosensors for biomarker detection and theranostic nanomedicine for imaging, gene and drug delivery, and monitoring of treatment.
1. Gao H, Kiesewetter DO, Zhang X, Huang X, Guo N, Lang L, Hida N, Wang H, Wang H, Cao F, Niu G, Chen X. PET of glucagonlike peptide receptor upregulation after myocardial ischemia or reperfusion injury. J Nucl Med. 2012;53(12):1960-8.
2. Swierczewska M, Choi KY, Mertz EL, Huang X, Zhang F, Zhu L, Yoon HY, Park JH, Bhirde A, Lee S, Chen X. A facile, one-step nanocarbon functionalization for biomedical applications. Nano Lett. 2012;12(7):3613-20.
3. Liu G, Choi KY, Bhirde A, Swierczewska M, Yin J, Lee SW, Park JH, Hong JI, Xie J, Niu G, Kiesewetter DO, Lee S, Chen X. Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate. Angew Chem Int Ed Engl. 2012;51(2):445-9.
4. Lang L, Li W, Guo N, Ma Y, Zhu L, Kiesewetter DO, Shen B, Niu G, Chen X. Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice. Bioconjug Chem. 2011;22(12):2415-22.